A new church could be set up above a bookmakers at the Plaza building in Trafalgar Road.
Christ Ladder Ministries has submitted a "change of use" planning application to Greenwich Council to have an area on the former cinema's first floor designated as a place of worship.
Most recently used as a restaurant, the first floor property above Ladbrokes already has planning consent to operate as an educational establishment.
See the Christ Ladder Ministries' planning application
Planning permission has also been given previously for the space to be converted into a three bedroom apartment.
At the time of writing, the church had not replied to a request for more information about its plans.
If the church gets the go-ahead, it will be but the latest twist in the eventful history of 234 Trafalgar Road. Next week Greenwich.co.uk profiles the building from the Granada cinema through to the current day.