A new church could be set up above a bookmakers at the Plaza building in Trafalgar Road.
Christ Ladder Ministries has submitted a "change of use" planning application to Greenwich Council to have an area on the former cinema's first floor designated as a place of worship.
Most recently used as a restaurant, the first floor property above Ladbrokes already has planning consent to operate as an educational establishment.
Planning permission has also been given previously for the space to be converted into a three bedroom apartment.
At the time of writing, the church had not replied to a request for more information about its plans.
If the church gets the go-ahead, it will be but the latest twist in the eventful history of 234 Trafalgar Road. Next week Greenwich.co.uk profiles the building from the Granada cinema through to the current day.